arXiv:2510.11300v1 Announce Type: cross Abstract: This paper proposes an agent-based approach toward a more natural interface between humans and machines. Large language models equipped with tools and the communication standard OPC UA are utilized to control machines in natural language. Instead of touch interaction, which is currently the state-of-the-art medium for interaction in operations, the proposed approach enables operators to talk or text with machines. This allows commands such as 'Please decrease the temperature by 20 % in machine 1 and set the motor speed to 5000 rpm in machine 2.' The large language model receives the user input and selects one of three predefined tools that connect to an OPC UA server and either change or read the value of a node. Afterwards, the result of the tool execution is passed back to the language model, which then provides a final response to the user. The approach is universally designed and can therefore be applied to any machine that supports the OPC UA standard. The large language model is neither fine-tuned nor requires training data, only the relevant machine credentials and a parameter dictionary are included within the system prompt. The approach is evaluated on a Siemens S7-1500 programmable logic controller with four machine parameters in a case study of fifty synthetically generated commands on five different models. The results demonstrate high success rate, with proprietary GPT 5 models achieving accuracies between 96.0 % and 98.0 %, and open-weight models reaching up to 90.0 %. The proposed approach of this empirical study contributes to advancing natural interaction in industrial human-machine interfaces.