arXiv:2509.16251v1 Announce Type: cross Abstract: State-of-the-art (SOTA) Convolutional Neural Networks (CNNs) are criticized for their extensive computational power, long training times, and large datasets. To overcome this limitation, we propose a reasonable network (R-Net), a lightweight CNN only to detect and classify colorectal cancer (CRC) using the Enteroscope Biopsy Histopathological Hematoxylin and Eosin Image Dataset (EBHI). Furthermore, six SOTA CNNs, including Multipath-based CNNs (DenseNet121, ResNet50), Depth-based CNNs (InceptionV3), width-based multi-connection CNNs (Xception), depth-wise separable convolutions (MobileNetV2), spatial exploitation-based CNNs (VGG16), Transfer learning, and two ensemble models are also tested on the same dataset. The ensemble models are a multipath-depth-width combination (DenseNet121-InceptionV3-Xception) and a multipath-depth-spatial combination (ResNet18-InceptionV3-VGG16). However, the proposed R-Net lightweight achieved 99.37% accuracy, outperforming MobileNet (95.83%) and ResNet50 (96.94%). Most importantly, to understand the decision-making of R-Net, Explainable AI such as SHAP, LIME, and Grad-CAM are integrated to visualize which parts of the EBHI image contribute to the detection and classification process of R-Net. The main novelty of this research lies in building a reliable, lightweight CNN R-Net that requires fewer computing resources yet maintains strong prediction results. SOTA CNNs, transfer learning, and ensemble models also extend our knowledge on CRC classification and detection. XAI functionality and the impact of pixel intensity on correct and incorrect classification images are also some novelties in CRC detection and classification.
