arXiv:2509.14778v1 Announce Type: new Abstract: Health informatics research is characterized by diverse data modalities, rapid knowledge expansion, and the need to integrate insights across biomedical science, data analytics, and clinical practice. These characteristics make it particularly well-suited for agent-based approaches that can automate knowledge exploration, manage complex workflows, and generate clinically meaningful outputs. Recent progress in large language model (LLM)-based agents has demonstrated promising capabilities in literature synthesis, data analysis, and even end-to-end research execution. However, existing systems remain limited for health informatics because they lack mechanisms to interpret medical visualizations and often overlook domain-specific quality requirements. To address these gaps, we introduce OpenLens AI, a fully automated framework tailored to health informatics. OpenLens AI integrates specialized agents for literature review, data analysis, code generation, and manuscript preparation, enhanced by vision-language feedback for medical visualization and quality control for reproducibility. The framework automates the entire research pipeline, producing publication-ready LaTeX manuscripts with transparent and traceable workflows, thereby offering a domain-adapted solution for advancing health informatics research.