arXiv:2509.01206v1 Announce Type: cross Abstract: Self-supervised monocular depth estimation is a significant task for low-cost and efficient three-dimensional scene perception in endoscopy. The variety of illumination conditions and scene features is still the primary challenge for generalizable depth estimation in endoscopic scenes. In this work, a self-supervised framework is proposed for monocular depth estimation in various endoscopy. Firstly, due to various features in endoscopic scenes with different tissues, a novel block-wise mixture of dynamic low-rank experts is proposed to efficiently finetuning the foundation model for endoscopic depth estimation. In the proposed module, based on the input feature, different experts with a small amount of trainable parameters are adaptively selected for weighted inference, from various mixture of low-rank experts which are allocated based on the training quality of each block. Moreover, a novel self-supervised training framework is proposed to jointly cope with the inconsistency of brightness and reflectance. The proposed method outperform state-of-the-art works on both realistic and simulated endoscopic datasets. Furthermore, the proposed network also achieves the best generalization based on zero-shot depth estimation on diverse endoscopic scenes. The proposed method could contribute to accurate endoscopic perception for minimally invasive measurement and surgery. The code will be released upon acceptance, while the demo video can be found on here: https://endo-gede.netlify.app/.