Biology is one of the areas in which AI and machine learning approaches have seen some spectacular successes, such as designing enzymes to digest plastics and proteins to block snake venom. But in an era of seemingly endless AI hype, it might be easy to think that we could just set AI loose on the mounds of data we've already generated and end up with a good understanding of most areas of biology, allowing us to skip a lot of messy experiments and the unpleasantness of research on animals.
But biology involves a whole lot more than just protein structures. And it's extremely premature to suggest that AI can be equally effective at handling all aspects of biology. So we were intrigued to see a study comparing a set of AI software packages designed to predict how active genes will be in cells exposed to different conditions. As it turns out, the AI systems couldn't manage to do any better than a deliberately simplified method of predicting.
The results serve as a useful caution that biology is incredibly complex, and developing AI systems that work for one aspect of it is not an indication that they can work for biology generally.
