cs.AI updates on arXiv.org 07月08日
Transformer Model for Alzheimer's Disease Progression Prediction Using Longitudinal Visit Sequences
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本文提出使用Transformer模型预测阿尔茨海默病进展阶段,通过分析患者就诊历史特征,与RNN等模型对比,模型在预测疾病进展和识别高风险患者方面表现优异,有助于提升早期诊断和患者治疗效果。

arXiv:2507.03899v1 Announce Type: cross Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder with no known cure that affects tens of millions of people worldwide. Early detection of AD is critical for timely intervention to halt or slow the progression of the disease. In this study, we propose a Transformer model for predicting the stage of AD progression at a subject's next clinical visit using features from a sequence of visits extracted from the subject's visit history. We also rigorously compare our model to recurrent neural networks (RNNs) such as long short-term memory (LSTM), gated recurrent unit (GRU), and minimalRNN and assess their performances based on factors such as the length of prior visits and data imbalance. We test the importance of different feature categories and visit history, as well as compare the model to a newer Transformer-based model optimized for time series. Our model demonstrates strong predictive performance despite missing visits and missing features in available visits, particularly in identifying converter subjects -- individuals transitioning to more severe disease stages -- an area that has posed significant challenges in longitudinal prediction. The results highlight the model's potential in enhancing early diagnosis and patient outcomes.

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阿尔茨海默病 Transformer模型 早期诊断 疾病进展预测 神经退化
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